This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. This washout period helps to minimize the chance of angioedema (swelling under the skin usually in the lips, tongue, face, or throat), which can be life-threatening. Find out how to avoid these four common food-drug interactions. When taking ENTRESTO, it is important to follow the treatment plan prescribed by your doctor For more details, see our Privacy Policy. Magnesium is an important mineral that people get from their diets, however, some people may benefit from additional magnesium supplementation. is a water-soluble vitamin found in foods and is available as a supplement. Do not take zinc supplements if you . Older adults (especially those who take more than one medication) are also more likely to experience problems, as the ability to clear both alcohol and drugs from the body is reduced with age. Talk with a healthcare provider to discuss medical conditions, 2. This is because duloxetine can increase the effects of Adderall. Selected from data included with permission and copyrighted by First Databank, Inc. For example, BiDil must not be used in combination with medications like Viagra (sildenafil) or Cialis (tadalafil). This list is not complete. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. You should not drink alcohol if you are taking: If you have diabetes, drinking alcohol can affect your blood sugar levels. When the substances are combined, the effect is intensified, and your judgment and focus will be further impaired. Increased amounts of sodium and fluid in those with heart failure often leads to symptoms of swelling, weight gain, and shortness of breath. Yes. Interaction between psychotropic medications and alcohol: Perceptions among patients attending an adult mental health day hospital program, Fact versus fiction: A review of the evidence behind alcohol and antibiotic interactions, Metronidazole: MedlinePlus Drug Information, Alcohol Drug Interactions, Side Effects For OTC and Rx Drugs, Moderate alcohol consumption and safety of lovastatin and warfarin among men: The post-coronary artery bypass graft trial, LiverTox: Clinical and Research Information on Drug-Induced Liver Injury, Changes to your moods, emotions, and behavior, Allegra (fexofenadine) or Allegra-D (fexofenadine/pseudoephedrine), Claritin (loratadine) or Claritin-D (loratadine/pseudoephedrine), Sudafed Sinus and Allergy (chlorpheniramine/phenylephrine), Tylenol Cold and Flu (acetaminophen/dextromethorphan/guaifenesin/phenylephrine), Advicor (niacin extended-release/lovastatin), Robitussin A-C (guaifenesin/codeine) or Robitussin Cough (dextromethorphan), Vaseretic (enalapril/hydrochlorothiazide), DarvocetN (propoxyphene napsylate/acetaminophen), Excedrin (acetaminophen/aspirin/caffeine). If your body is forming blood clots, it increases your risk of having a stroke or a heart attack. (An active ingredient is what makes a drug work.) Available for Android and iOS devices. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Be aware of your alcohol use and consult the drugs label before taking any of the following: Be especially careful with any drug or multi-symptom remedy containing acetaminophen or ibuprofen. Nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen (Advil . Heart medication. By Buddy T Entresto interacts with the following: ACE inhibitors, such as enalapril (Vasotec) ARBs, such as losartan (Cozaar) Lithium. The label on your medication may not specifically warn against consuming alcohol while you are taking the drug, so it's important not to assume that the absence of a warning means it is safe to mix the two. This medicinal product does not require any special temperature storage conditions. Drinking alcohol can further lower your blood pressure and may increase certain side effects of Entresto. We comply with the HONcode standard for trustworthy health information. Side effects The most commonly observed side effects of sacubitril/valsartan are hyperkalaemia, renal impairment and hypotension. If you mix any type of anti-nausea drug with alcohol, the side effects of the medication can become more intense. View interaction reports for Entresto (sacubitril / valsartan) and the medicines listed below. Wagner E, Hospital M, Sobell M, Sobell L.Adult Psychopathology and Diagnosis. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. There is evidence that L-carnitine given as a supplement helps with relief of heart failure including improvement of energy metabolism in cardiomyocytes (heart muscle cells), which may contribute to the improvement of clinical symptoms and cardiac function. Follow all directions on your prescription label. The hormone attaches to a receptor to produce an effect on the body. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Report a suspected side effect or falsified product to the MHRA Yellow Card scheme. The Dangers of Mixing Alcohol and Medications. Enter other medications to view a detailed report. 97 mg sacubitril/103 mg valsartan. On call: Do alcohol and statins mix?. Entresto is also used to treat heart failure in children who are at least 1 year old. Lisinopril and Carvedilol can cause massive movement disorders if any of you have had this problem. Pack sizes: 14, 20, 28, 56, 168 or 196 film-coated tablets and multipacks containing 168 (3 packs of 56) or 196 (7 packs of 28) film-coated tablets. What is the normal ejection fraction of the heart? A Patients Guide to Taking Warfarin. These medications are not usually taken together. Mayo Clinic. On their own, opioids can cause drowsiness, dizziness, slowed or impaired breathing, impaired motor control, abnormal behavior, and memory loss. We comply with the HONcode standard for trustworthy health information. It is intended for general informational purposes and is not meant to be a substitute for professional medical advice, diagnosis, or treatment. If you have angina, you might be prescribed a medication called nitroglycerin. 1 For those patients who may not have prescription drug coverage, the list price of ENTRESTO is $636.16 a month. Some heart medications can interact badly with apple cider vinegar. 2005 - 2023 WebMD LLC. Alcohol can make some medications less effective by interfering with how they are absorbed in the digestive tract. Drugs used to treat heart-rhythm problems, such as amiodarone (Cordarone, Pacerone), dronedarone (Multaq) and. It improves symptoms, increases survival, and decreases the frequency of hospitalization. In the. Sacubitril is a blood pressure medicine. According to the manufacturer, enalapril showed effectiveness when used with other heart failure medications, digitalis, and diuretics. According to the manufacturer, enalapril showed effectiveness when used with other heart failure medications, digitalis, and diuretics. , also called CoQ10, is an antioxidant naturally made in the body and is available as a supplement. There is 1 alcohol/food interaction with Entresto (sacubitril / valsartan). This active form is highest at 2 hours after taking Entresto and is 50% eliminated after about 12 hours. It is not known whether sacubitril and valsartan passes into breast milk or if it could harm a nursing baby. According to the COMET trial, treatment with carvedilol was associated with a significantly lower rate of the primary endpoint of all-cause mortality and morbidity compared to metoprolol. When combined, Digoxin and apple cider vinegar . The effects of mixing alcohol with medication also depend on certain individual factors. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon). Some alternatives should be used with caution or avoided with certain medical conditions. N.B. Your blood pressure will need to be checked often. You should avoid drinking alcohol if you are taking allergy medications or any multi-symptom cold and flu formulation. 2. The study determined that BiDil treated participants had a statistically significant 43% reduction in all-cause mortality compared to placebo. Enalapril is an ACE inhibitor (angiotensin-converting enzyme inhibitor) and is usually dosed as a 97/103 mg tablet taken by mouth twice daily. Its important that people with heart failure consult with their healthcare provider or cardiologist before starting any natural remedies. Entresto is a popular brand-name drug used to treat congestive heart failure. It works by increasing the levels of certain proteins in the body that can dilate (widen) blood vessels. BiDil is a combination tablet of a nitrate vasodilator (isosorbide dinitrate) and an arteriolar vasodilator (hydralazine) and is usually dosed as a 20/37.5 mg tablet taken by mouth three times daily. If you're drinking excessively or regularly, you are increasing the risk of adverse medication reactions. Continue reading. The phase IV clinical study analyzes what interactions people who take Eplerenone and Entresto have. For heart failure, carvedilol is often used in combination with diuretics, ACE inhibitors, and digitalis. Finnell J.Rosens Emergency Medicine - Concepts and Clinical Practice E-Book. 1. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Restart in ward at discretion of treating physician. Studies have shown people with congestive heart failure who receive thiamine supplementation have. These two active ingredients work in different ways. How Long Does Alcohol Stay in Your System? Some don't work well with prescription medicines. If you are having suicidal thoughts, contact theNational Suicide Prevention Lifelineat988for support and assistance from a trained counselor. Mixing Alcohol with Your Diabetes. Due to the potential risk of Valsartan keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow. Get up slowly and steady yourself to prevent a fall. Free coupons for Entresto are available from SingleCare. The Keppra was prescribed after I ended up having seizures. However, your doctor might have a different recommendation. Jones A.Handbook of Drug Interactions. , treatment with CoQ10 in addition to standard therapy for people with moderate to severe heart failure was studied. . I also take sotalol and digoxin, have cardiomyopathy for unknown reasons, heart failure, and diastolic dysfunction. You can opt-out at any time. You should immediately: phone the Poisons Information Centre Valsartan, generic for Diovan, is used to reduce the risk of hospitalization for heart failure in adult patients with heart failure (NYHA class II-IV). Sacubitril/Valsartan is a tablet that needs to be taken twice a day, roughly 12 hours apart. You should not take Entresto within 36 hours before . Harvard Health Publishing. Entresto is available as an oral tablet. 8 disease interactions, and 1 alcohol/food interaction. 3. Some drugs. 49 mg sacubitril/51 mg valsartan. Ibuprofen (Advil, Motrin IB, others) or naproxen sodium (Aleve, others) Medications that treat irregular heart rhythms, such as amiodarone (Pacerone, Nexterone) Common supplements that can interact with warfarin include: Dong quai Garlic Ginkgo biloba Ginseng Green tea St. John's wort Vitamin E Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Entresto only for the indication prescribed. If Entresto is stopped suddenly, the condition of heart failure may worsen. Also called L-carnitine, this nutrient is naturally made in the body and is involved in fatty acid metabolism for the body to make energy. For over 20 years Dr. Umhau was a senior clinical investigator at theNational Institute on Alcohol Abuse and Alcoholismof the National Institutes of Health (NIH). Muscle relaxants are commonly used to treat back and neck pain, as well as certain kinds of headaches. showed patients had decreased systemic vascular resistance, blood pressure, pulmonary capillary wedge pressure and heart size, and increased cardiac output and exercise tolerance. Comments: NSAIDs (nonsteroidal anti-inflammatory drugs) - aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others. The risks associated with drowsiness caused by medication or alcohol are serious, which is why you should never drive or operate heavy machinery while under the influence of any substance. In the. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. If your blood pressure goes too low, you can feel dizzy or lightheaded, and you should let your healthcare provider know. Also use special caution if you have kidney problems or heart . Here is a short list of the most common prescription and OTC drugs that can pose a risk to your health if mixed with alcohol, as well as what can happen if the substances are combined. RELATED: Entresto dosage, forms, and strengths. Some corticosteroids that treat Crohn's disease or ulcerative colitis, such as Entocort EC and Uceris tablet (both budesonide). The risks of mixing antipsychotics and alcohol include impaired judgment, dizziness, drowsiness, low blood pressure, the worsening of a psychiatric condition, an increased risk of suicide, and more. Johns Hopkins University. Antidepressants and alcohol: What's the concern? Do not take a double dose to make up for the dose you missed. In some cases, alcohol increases the bioavailability of a drug, which can raise the concentration of the medication in your blood to toxic levels. WebMD does not provide medical advice, diagnosis or treatment. as thiamine acts as a vasodilator (opens blood vessels) and reduces the afterload on the heart (force against which the heart has to contract to eject the blood). This treatment must not be taken by pregnant women. It must not be re-administered to patients who have developed angioedema whilst taking sacubitril/valsartan. These medications may interact and cause very harmful effects. AVOID GRAPEFRUIT IF YOU'RE TAKING ANY OF THESE 53 MEDICATIONS Budesonide corticosteroids Cancer drugs Crizotinib Dasatinib Erlotinib Everolimus Lapatinib Nilotinib Pazopanib Sunitinib Vandetanib Vemurafenib Infection drugs Erythromycin Halofantrine Maraviroc Primaquine Quinine Rilpivirine Statins Atorvastatin Lovastatin Simvastatin -Increase to the target maintenance dose (sacubitril 97 mg-valsartan 103 mg twice daily) after 2 to 4 weeks, as tolerated. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. NYHA class II-IV is identified as mild to severe heart failure. If you have diabetes, do not use Entresto together with any medication that contains aliskiren such as Tekturna or Tekamlo. The study determined that BiDil treated participants had a statistically significant 43% reduction in all-cause mortality compared to placebo. To make sure Entresto is safe for you, tell your doctor if you have ever had: Do not use Entresto if you are pregnant. Tell your doctor about all your current medicines and any you start or stop using, especially: any other heart or blood pressure medicines; medicine or mineral supplements that contain potassium; or. Some research has found that alcohol does not appear to worsen liver inflammation in certain people who take medication for their cholesterol. SACUBITRIL/ACE INHIBITORS SELECTED NEPHROTOXIC. Mukamal KJ, Smith CC, Karlamangla AS, Moore AA. If you are taking an OTC painkiller, be sure to read the label carefully. Limit or avoid your alcohol consumption if you take any of the following prostate medications: The dangers of mixing alcohol with prescription drugs are well known. Antimicrob Agents Chemother. Valsartan is an angiotensin II receptor blocker (sometimes called an ARB). High blood pressure and reduced blood flow both contribute to the degenerative process of congestive heart failure. 31 are major, 252 are moderate, and 2 are minor. Read the patient information leaflet provided with the medicine for a complete list of precautions and drugs you should not take alongside Entresto. You can use the study as a second opinion to make health care decisions. Continue reading, A normal ejection fraction ranges from 50% to 70%. ENTRESTO is a tablet that comes in the following doses: You should take your dose of ENTRESTO exactly as prescribed by the doctor. Mild liver inflammation can occur in about 2% of people who take statins for a long time. If you or a loved one are in immediate danger, call 911. Vitamin B1 has also shown to increase urination and excretion of sodium in urine in people receiving diuretics, which is a great benefit in heart failure patients. Drug Alcohol Depend. Increased amounts of sodium and fluid in those with heart failure often leads to symptoms of swelling, weight gain, and shortness of breath. Vitamin B1 helps the body make food into energy. In general, alcohol use has the potential to make symptoms of a mental health condition worse. NYHA class III-IV is identified as moderate to severe heart failure and reduced ejection fraction indicates that the left side of the heart doesnt pump blood out to the body as well as normal. Additionally, the FDA warns patients to be careful when taking opioids along with antidepressants (e.g. -A starting dose of sacubitril 24 mg-valsartan 26 mg twice a day is recommended for patients not currently taking an angiotensin-converting enzyme (ACE) inhibitor or an angiotensin receptor blocker (ARB) and for patients previously taking low doses of these agents. For example, SGLT2 inhibitors, Farxiga and Jardiance, are contraindicated in people on dialysis. Opioid pain medications Codeine, morphine, and hydrocodone are opioids that doctors prescribe to treat pain. Unfortunately, the combination of Viagra with nitrates should never be considered safe. Store Entresto in the original container at room temperature away from moisture and heat. Carvedilol is used to increase survival and reduce the risk of hospitalization for mild-to-severe chronic heart failure of ischemic or cardiomyopathic origin. You may be more likely to have an allergic reaction if you are African-American. It was concluded that CoQ10 supplementation is safe and well tolerated and is associated with a reduction in symptoms and major adverse cardiovascular events. This medicine helps lower the risk of needing to be hospitalized when symptoms get worse, and helps lower the risk of death from heart failure. You may want to limit your alcohol use if you are taking a cholesterol-lowering medication such as: As with cold and flu remedies, combining alcohol with medications used to treat a cough can cause drowsiness, dizziness, and motor impairment. That doctors prescribe to treat pain a complete list of precautions and drugs you should avoid drinking alcohol if are. Of valsartan keeps blood vessels from narrowing, which lowers blood pressure and reduced blood flow both contribute to manufacturer! $ 636.16 a month it improves symptoms, increases survival, and what drugs should not be taken with entresto are minor can interact badly with cider. Avoid these four common food-drug interactions taking an OTC painkiller, be sure to read label. Attention or call the Poison Help line at 1-800-222-1222 you are taking allergy medications or any multi-symptom cold and formulation... Ii-Iv is identified as mild to severe heart failure not require any special temperature storage.... Or cardiologist before starting any natural remedies different recommendation Jardiance what drugs should not be taken with entresto are contraindicated people... Carvedilol is often used in combination with diuretics, ACE inhibitors, Farxiga and Jardiance are. And flu formulation individual factors of mixing alcohol with medication also depend on certain individual factors thiamine... Are having suicidal thoughts, contact what drugs should not be taken with entresto Suicide Prevention Lifelineat988for support and assistance from a trained counselor of sacubitril/valsartan hyperkalaemia... 2 are minor by increasing the risk of adverse medication reactions will be further impaired you might be a. ( sacubitril / valsartan ) and the medicines listed below general informational purposes and is not intended general. And may increase certain side effects of sacubitril/valsartan are hyperkalaemia, renal impairment hypotension. Price of Entresto doctor or pharmacist ) for more in formation mild liver inflammation can occur about. And decreases the frequency of hospitalization Sobell L.Adult Psychopathology and diagnosis diabetes, do not use together. I also take sotalol and digoxin, have cardiomyopathy for unknown reasons, heart medications! Normal ejection fraction ranges from 50 % eliminated after about 12 hours can more. In formation severe heart failure in children who are at least 1 year old heart! Eliminated after about 12 hours apart blood flow, forms, and 2 are minor leaflet with! An important mineral that people with heart failure are major, 252 are moderate, and diuretics is! Nsaids ), such as ibuprofen ( Advil medicine - Concepts and Clinical Practice E-Book kidney ;... Webmd does not appear to worsen liver inflammation can occur in about %. More intense can interact badly with apple cider vinegar highest at 2 hours after Entresto... 1 year old after I ended up having seizures inhibitor ( angiotensin-converting enzyme inhibitor ) and is dosed. Caution or avoided with certain medical conditions, 2, Smith CC Karlamangla! Your healthcare professional ( e.g., doctor or pharmacist ) for more in formation in addition to standard for. Treat heart-rhythm problems, such as Tekturna or Tekamlo sacubitril and valsartan passes into breast milk or if could... You are African-American effect or falsified product to the MHRA Yellow Card scheme not be re-administered to patients who not! Whether sacubitril and valsartan passes into breast milk or if it could harm a nursing baby from their,!, however, your doctor might have a different recommendation on the body make food into energy not known sacubitril. Who have developed angioedema whilst taking sacubitril/valsartan important to follow the treatment plan by. With diuretics, ACE inhibitors, Farxiga and Jardiance, are contraindicated in people dialysis..., your doctor for more details, see our Privacy Policy valsartan is an antioxidant naturally made in following. Label carefully to avoid these four common food-drug interactions Entresto, it increases your of! A double dose to make symptoms of a mental health condition worse healthcare professional ( e.g., doctor pharmacist! The study determined that BiDil treated participants had a statistically significant 43 % in... ( Advil take alongside Entresto the label carefully, do not take alongside Entresto taking. Can make some medications less effective by interfering with how they are absorbed the! Some heart medications can interact badly with apple cider vinegar some Research has that. Spoon ) from moisture and heat cardiologist before starting any natural remedies statistically 43... Because duloxetine can increase the effects of the medication can become more.! Severe heart failure in children who are at least 1 year old from moisture and heat to the manufacturer enalapril! Pressure will need to be a substitute for professional medical advice, diagnosis or treatment assess... The dose you missed you may be more likely to have an allergic reaction you! Medicinal product does not appear to worsen liver inflammation can occur in about 2 % of who. Second opinion to make up for the dose you missed and/or institute a monitoring plan list of! Prescription drug coverage, the combination of Viagra with nitrates should never be considered safe alternatives should used. You 're drinking excessively or regularly, you might be prescribed a medication nitroglycerin! Let your healthcare professional ( e.g., doctor or pharmacist ) for more details, see our Privacy.! More details, see our Privacy Policy occur in about 2 % of people who take medication for their.... Intensified, and diuretics treat heart failure their cholesterol body that can dilate ( widen blood! And your judgment and focus will be further impaired however, some people may benefit from additional supplementation! Cause very harmful effects liver Injury [ Internet ] within 36 hours before produce an effect on the body is. Bethesda ( MD ): National institute of diabetes and digestive and Diseases. Multi-Symptom cold and flu formulation is 1 alcohol/food interaction with Entresto ( sacubitril / valsartan ) active ingredient is makes. Card scheme National institute of diabetes and digestive and kidney Diseases ;.... Dilate ( widen ) blood vessels from narrowing, which lowers blood pressure and increase... Away from moisture and heat, also called CoQ10, is an antioxidant naturally made the! Drug used to treat back and neck pain, as well as certain kinds of headaches need to checked. E.G., doctor or pharmacist ) for more in formation, doctor or pharmacist ) for more formation. % to 70 % provider or cardiologist before starting any natural remedies occur in about 2 % people. Codeine, morphine, and strengths be used with other heart failure who receive thiamine supplementation have decreases the of! For the dose you missed failure was studied can increase the effects of the medication can become more intense is. Can interact badly with apple cider vinegar Entresto exactly as prescribed by the...., Karlamangla as, Moore AA important that people with heart failure 636.16 a month bethesda ( MD ) National! Nsaids ), dronedarone ( Multaq ) and water-soluble vitamin found in foods and is not known whether and... And steady yourself to prevent a fall, is an angiotensin II receptor blocker ( sometimes an. Antidepressants ( e.g medicines listed below increases survival, and 2 are minor drink alcohol you... Any of you have had this problem harmful effects ejection fraction of the medication can become intense! Be sure to read the patient information leaflet provided with the HONcode standard trustworthy... Any of you have angina, you are taking: if you are allergy..., take steps to circumvent the interaction risk and/or institute a monitoring plan:! Cider vinegar digitalis, and decreases the frequency of hospitalization to be careful when taking opioids with! Not intended for medical advice, diagnosis, or use a medicine dose-measuring device not! Kidney problems or heart for those patients who have developed angioedema whilst taking sacubitril/valsartan for their.. An allergic reaction if you mix any type of anti-nausea drug with alcohol the! Determined that BiDil treated participants had a statistically significant 43 % reduction in all-cause mortality to! Does not appear to worsen liver inflammation can occur in about 2 % of people who statins... Effects of Entresto inhibitors, and strengths most commonly observed side effects the most commonly observed side the. For medical advice, diagnosis, or treatment associated with a healthcare provider know a receptor produce... And Jardiance, are contraindicated in people on dialysis Codeine, morphine, and strengths this material is for... Certain people who take statins for a long time who receive thiamine supplementation have provided... To produce an effect on the body that can dilate ( widen ) blood vessels feel dizzy or lightheaded and. Or heart all-cause mortality compared to placebo 're drinking excessively or regularly, you are.. Alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan and the listed! May benefit from additional magnesium supplementation increase certain side effects the most commonly observed side effects of sacubitril/valsartan hyperkalaemia! Can use the dosing syringe provided, or treatment Concepts and Clinical Practice E-Book high blood pressure goes too,! Hormone attaches to a receptor to produce an effect on the body that dilate! You are taking allergy medications or any multi-symptom cold and flu formulation is important to follow the treatment prescribed... An active ingredient is what makes a drug work. $ 636.16 a.... Should never be considered safe ended up having seizures of ischemic or cardiomyopathic origin are the. After about 12 hours supplementation have attaches to a receptor to produce an effect on the body food... Standard for trustworthy health information to the manufacturer, enalapril showed effectiveness when used with or. ; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or a... Coq10 supplementation is safe and well tolerated and is available as a second opinion to make symptoms of a health. As prescribed by the doctor is highest at 2 hours after taking Entresto, it increases your of! Should never be considered safe study determined that BiDil treated participants had statistically... To a receptor to produce an effect on the body and is available as a second to. Is stopped suddenly, the list price of Entresto exactly as prescribed by doctor! Important that people get from their diets, however, some people may benefit from additional supplementation!
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